Story byMike Masala, Niners WireMon, December 22, 2025 at 5:15 AM UTC·2 min readThe San Francisco 49ers are traveling in Week 16 for an interconference matchup with the Indianapolis Colts on Monday night at Lucas Oil Stadium. San Francisco has won four in a row since starting quarterback Brock Purdy returned from the toe injury that cost him eight starts. Their offense will be without second-year wide receiver Ricky Pearsall, who caught six passes for 96 yards last week against the Tennessee Titans. They'll need to find someone else to make an impact in the passing game alongside George Kittle, Christian McCaffrey and Jauan Jennings. AdvertisementAdvertisementAdvertisementThe Colts are going the opposite direction, losing their last four games after starting the year with an 8-2 record.
