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Story byVinnie IyerSat, December 20, 2025 at 5:15 AM UTC·12 min readFantasy Football Start 'Em, Sit 'Em Week 16: Who should I start, lineup advice, best matchups, DFS picks originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. JUMP TO:Start-Sit Week 16 QBStart-Sit Week 16 RBStart-Sit Week 16 WRStart-Sit Week 16 TEStart-Sit Week 16 D/STWelcome to the Week 16 edition of fantasy football starts and sits from The Sporting News. AdvertisementAdvertisementAdvertisement"The Decider" is your one-stop shop for fantasy start/sit lineup advice in 2025 -- a unique mashup of rankings and matchup breakdowns to help you make those tough decisions on whom to play and not to play:There are several high-drafted fantasy players who should be in lineups every week when they're active. Those are the "regular starts."For those borderline options with favorable matchups, they are "stronger starts," while the recommended sits are "weaker starts."We're also basing our advice on 12-team, half-point PPR to split the difference between shallow and deep leagues and full-PPR and standard formats. Going beyond the redraft league starts and sits, "The Decider" also includes some DFS picks for different styles of daily fantasy sports games on DraftKings and FanDuel. Keep scrolling for how to put the best fantasy football lineups on "the field" for your critical Week 16 game with tips on starts and sits this week.➕ UPGRADE YOUR TOOLS FOR THE PLAYOFFS: Sign up for Yahoo Fantasy PlusFantasy Football Week 16 Start 'Em: QuarterbacksMust-start Week 16 QBsJalen Hurts, Eagles (vs.
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