Story byKyle Madson, Niners WireMon, December 29, 2025 at 7:56 AM UTC·1 min readThe San Francisco 49ers are dealing with a handful of new injuries exiting their thrilling Week 17 win over the Chicago Bears on Sunday night. With George Kittle already on the sidelines because of an ankle injury, left tackle Trent Williams went out on the first play of the game leaving the 49ers without two of their best offensive players. Williams is dealing with a hamstring injury and head coach Kyle Shanahan didn't have any kind of timeline for his return after the game. AdvertisementAdvertisementAdvertisement"I'm not sure," Shanahan said. "I mean, he tried to go and he couldn't, so Trent told me he has never pulled a hamstring before, so not really sure how it will be.”It wouldn't be a huge surprise if the 49ers hold Williams out of the team's season finale against Seattle on Saturday.