Health

Losing weight in midlife may have a hidden brain cost

December 28, 2025

Science News from research organizations Losing weight in midlife may have a hidden brain cost Date: December 28, 2025 Source: Ben-Gurion University of the Negev Summary: Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened inflammation in a brain region tied to appetite and energy balance. While this inflammation eventually subsided, brain inflammation has been linked to cognitive decline and neurodegenerative disease.

Weight loss may boost metabolism in midlife, but it could also quietly stress the brain

Credit: Shutterstock

Key Highlights

The results suggest that weight loss in midlife may not be as straightforward as once thought.
Share: Facebook Pinterest LinkedIN Email FULL STORY Weight loss may boost metabolism in midlife, but it could also quietly stress the brain.
Credit: Shutterstock Obesity remains one of the most serious health challenges worldwide, and weight loss is often encouraged as a way to lower the risks tied to excess weight.
But growing research suggests that the effects of weight loss may change with age.
During midlife, losing weight may not always produce the same health benefits seen in younger adults and in some cases, it may also influence brain health.

Sources

Losing weight in midlife may have a hidden brain cost

This quick summary is automatically generated using AI based on reports from multiple news sources. The content has not been reviewed or verified by humans. For complete details, accuracy, and context, please refer to the original published articles.

Losing weight in midlife may have a hidden brain cost

Key Highlights

Sources

Related Stories

Foraged mushrooms in California linked to three deaths

‘Walk like penguin’ to avoid adding to winter trip toll

Travel Influencer Ignored Fatigue Symptoms; Had a Heart Attack at Just 24