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NFL betting, odds, lines: Betting trends to know for Week 16's biggest games

Story byMatt JacobContributing writerFri, December 19, 2025 at 2:58 PM UTC·8 min readA prime-time battle for first place in the NFC North. Followed by another clash between rivals tied atop the NFC South. Plus a showdown between two red-hot AFC division leaders, and a Sunday Night Football contest in which a .500 AFC North squad is favored over the 11-win leader of the AFC East. AdvertisementAdvertisementAdvertisementNeedless to say, NFL schedule-makers hit the jackpot in Week 16. Now let’s see if we can help you hit the jackpot by breaking down a slew of current and historical NFL betting trends related to all four of these highly intriguing matchups. All listed odds are via BetMGM and subject to change. Green Bay Packers (-1, 46.5) at Chicago BearsKickoff: Saturday, 8:20 p. m.

NFL betting, odds, lines: Betting trends to know for Week 16's biggest games

Credit: Yahoo

Key Highlights

  • ETMoneyline: Packers -115/Bears +105• The NFC North’s top two teams hook up for the second time in three weeks, this time in the Windy City. Back in Week 14, the Packers welcomed Chicago to Lambeau Field and held on 28-21, barely cashing as 6.5-point home favorites. AdvertisementAdvertisementAdvertisementFrom there, Green Bay took its season-best four-game SU and three-game ATS winning streaks to Denver and saw both go up in flames in a 34-26 loss as 1.5-point road chalk. Conversely, the Bears rebounded from the disappointing defeat in Wisconsin by blasting Cleveland 31-3 in Week 15, easily covering as 7.5-point favorites.• When it comes to impressive NFL betting trends, it’s difficult to top Green Bay’s utter dominance of the Bears that dates back nearly two decades. The Packers have won 29 of 35 head-to-head meetings since 2008 (going 26-9 ATS), including 12 of 13 since 2019 (11-2 ATS). What’s more, Green Bay has made Soldier Field a second home for the past 17 years, going 15-2 SU and 13-4 ATS.
  • That includes an ongoing six-game winning streak in Chicago (5-1 ATS). AdvertisementAdvertisementAdvertisement• The Packers are 4-2-1 SU  on the road but just 2-5 ATS. On the other hand, Chicago is 10-2 since Week 3 (8-3-1 ATS), including an active five-game home winning streak (3-1-1 ATS).• Green Bay has cleared the closing total in three straight games overall and four of the last five.
  • The over is also 6-0 in the Packers’ last six as a visitor. The total has alternated in the Bears’ last four contests, with Sunday’s game against the Browns staying low.
  • In fact, the under has hit in four of the last five at Soldier Field. Tampa Bay Buccaneers (-3, 45.5) at Carolina PanthersKickoff: Sunday, 1 p. m.
  • ETAdvertisementAdvertisementAdvertisementMoneyline: Buccaneers -155/Panthers +130• In another Week 16 division rivalry matchup involving playoff contenders, the slumping Buccaneers visit Carolina.
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Sources

  1. NFL betting, odds, lines: Betting trends to know for Week 16's biggest games

This quick summary is automatically generated using AI based on reports from multiple news sources. The content has not been reviewed or verified by humans. For complete details, accuracy, and context, please refer to the original published articles.

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