Health

Psychedelic reduces depression symptoms after just one dose

February 16, 2026

A recent small clinical trial has shown that a single dose of the psychedelic drug dimethyltryptamine (DMT) can lead to rapid and sustained improvements in depressive symptoms, especially when combined with psychotherapy. While DMT is heavily regulated and considered to have high abuse potential, its use in therapeutic settings is gaining attention as a potential treatment for those who do not respond to traditional antidepressants.

Psychedelic reduces depression symptoms after just one dose

Credit: wildpixel/Getty Images

Key Highlights

DMT is a potent psychedelic found in various plants and used in shamanistic rituals.
The trial involved 34 participants suffering from major depressive disorder.
Participants experienced a significant reduction in depressive symptoms after one dose of DMT.
The effects were noted to be rapid and long-lasting, especially when combined with psychotherapy.
DMT is subject to strict international control due to concerns over its abuse potential.

Medical research Drugs Depression Mental health Health Science UK news Society

Sources

This quick summary is automatically generated using AI based on reports from multiple news sources. The content has not been reviewed or verified by humans. For complete details, accuracy, and context, please refer to the original published articles.

Psychedelic reduces depression symptoms after just one dose

Key Highlights

Sources

Related Stories

Professor who reportedly paused UK puberty blockers trial recused over ‘bias’

A U.S. scholarship thrills a teacher in India. Then came the soul-crushing questions

Touch, sound and style: how London fashion week is opening up to visually impaired guests – photo essay