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The 4x rule: Why some people’s DNA is more unstable than others

A recent genetic study highlights that some individuals possess DNA sequences that expand with age, which can lead to increased instability in their genetic material. This instability can be influenced by common genetic variants that may accelerate the expansion rate by up to four times, and certain expansions have been associated with serious kidney and liver diseases.

Repeated DNA sequences grow longer and more unstable with age, and genetics plays a powerful role in controlling the speed of this process. In some people, these changes are linked to serious diseases, revealing a hidden source of health risk

Repeated DNA sequences grow longer and more unstable with age, and genetics plays a powerful role in controlling the speed of this process. In some people, these changes are linked to serious diseases, revealing a hidden source of health risk

Credit: Shutterstock

Key Highlights

  • DNA sequences in some individuals expand as they age.
  • Common genetic variants can increase the expansion rate by four times.
  • Specific DNA expansions are linked to severe kidney and liver diseases.
  • Age-related DNA instability is more prevalent than previously thought.
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Sources

  1. The 4x rule: Why some people’s DNA is more unstable than others

This quick summary is automatically generated using AI based on reports from multiple news sources. The content has not been reviewed or verified by humans. For complete details, accuracy, and context, please refer to the original published articles.

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