Who plays on 'Monday Night Football' tonight? Time, TV channel, schedule, live stream for NFL Week 16 game

Key Highlights

• Injuries have been a theme for each; for San Francisco, virtually every big name on its veteran roster has missed some kind of time in 2025. It's Indianapolis' quarterback situation that will be in the spotlight though, as the 44-year-old Philip Rivers trots back out for his second start after making a shocking return to the NFL in Week 15 as a fill-in starter after Daniel Jones' injury. After nearly taking down the Seahawks last week, Rivers will be seeking his first win in five years against the 49ers.
• Meanwhile, Kyle Shanahan's unit will be eyeing a win to come closer to locking in a playoff spot. Here's everything you need to know about watching Monday Night Football, including TV and streaming information for 49ers vs.
• Colts. AdvertisementAdvertisementAdvertisementWho plays on Monday Night Football tonight?Matchup: 49ers vs.
• ColtsLocation: Lucas Oil Stadium in Indianapolis, IndianaThe Colts host the 49ers on Monday Night Football in Week 16, with the game set to be played at Lucas Oil Stadium in Indianapolis, Indiana. What time is the NFL game on tonight?Date: Monday, Dec.
• 22Time: 8:15 p. m.